ChloroquineV1, Main, Exploration, bibRecord, 001B95

A Case of Hyper-reactive Malarial Splenomegaly. The Role of Rapid Antigen-detecting and PCR-based Tests

Identifieur interne : 001B95 ( Main/Exploration ); précédent : 001B94; suivant : 001B96

A Case of Hyper-reactive Malarial Splenomegaly. The Role of Rapid Antigen-detecting and PCR-based Tests

Auteurs : B. Mothe [Espagne] ; J. Lopez-Contreras [Espagne] ; O. H. Torres [Espagne] ; C. Mu Oz [Espagne] ; P. Domingo [Espagne] ; M. Gurgui [Espagne]

Source :

Infection [ 0300-8126 ] ; 2008-04-01.

RBID : ISTEX:0AFDE34E394F56BE6315B3021FACAD2BD2CE39B7

Abstract

Abstract: Hyper-reactive malarial splenomegaly (HMS) – originally referred to as tropical splenomegaly syndrome – is characterized by a massive splenomegaly, high titres of anti-malarial antibodies and polyclonal IgM hypergammaglobulinemia. It is believed to be a consequence of an aberrant immunological response to prolonged exposure to malarial parasites. Although it is a frequent disease in the tropics, it is infrequent in western countries and is only seen in long-term residents from endemic areas. We describe the case of a 67-year-old Spanish man, a missionary in Cameroon for 30 years, who presented with a clinical history that fulfilled the diagnosis of HMS. We discuss the role and importance of PCR-based techniques in demonstrating lowgrade malarial parasitemia and the usefulness of new rapid antigen-detecting dipstick tests.

Url:

https://api.istex.fr/ark:/67375/VQC-HS0M5G0R-2/fulltext.pdf

DOI: 10.1007/s15010-007-6025-z

Affiliations:

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<front><div type="abstract" xml:lang="en">Abstract: Hyper-reactive malarial splenomegaly (HMS) – originally referred to as tropical splenomegaly syndrome – is characterized by a massive splenomegaly, high titres of anti-malarial antibodies and polyclonal IgM hypergammaglobulinemia. It is believed to be a consequence of an aberrant immunological response to prolonged exposure to malarial parasites. Although it is a frequent disease in the tropics, it is infrequent in western countries and is only seen in long-term residents from endemic areas. We describe the case of a 67-year-old Spanish man, a missionary in Cameroon for 30 years, who presented with a clinical history that fulfilled the diagnosis of HMS. We discuss the role and importance of PCR-based techniques in demonstrating lowgrade malarial parasitemia and the usefulness of new rapid antigen-detecting dipstick tests.</div>
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A Case of Hyper-reactive Malarial Splenomegaly. The Role of Rapid Antigen-detecting and PCR-based Tests

A Case of Hyper-reactive Malarial Splenomegaly. The Role of Rapid Antigen-detecting and PCR-based Tests

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Abstract

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